The Co-Evaluation of Endosalpingeal Edema and Karyorrhexis after the "U-74389G" Effect on Fallopian Ischemia Reperfusion Injury

Aim: This study co-evaluated the 2 quoted histologic variables after the antioxidant lazaroid agent “U74389G” (L) administration. The calculation was based on the results of 2 preliminary studies, each one evaluating a respective histologic variable of endosalpingeal edema (E) or endosalpingeal karyorrhexis (K) in an induced ischemia reperfusion (IR) animal experiment.

Materials and methods: The 2 main experimental endpoints at which the E and K scores were evaluated, were the reperfusion 60th min (for A & C groups) and the reperfusion 120th min (for B & D groups). Specially, the groups A and B were processed without drugs, whereas the groups C and D after L administration. Results: The first preliminary study showed that L non significantly deflated the E scores by the grade “without lesions” 0.0226438 [-0.0493716 - 0.0040841] (p-value=0.0945). The second preliminary study showed that L did not influence the K scores by the grade “without lesions” 0.00 (p-value=1.0000). Both studies were co-estimated since they belong to the same experimental setting. This study co-evaluated the combined diagnostic values of both variables together. Conclusions: L hardly non significantly inflated both scores for these histologic parameters at the grade of “without lesions” 0.0113219 [-0.0246858 - 0.002042] (p-value=0.0945) since they were co-evaluated together.

Keywords: ischemia, U-74389G, endosalpingeal edema, endo salpingeal karyorrhexis, reperfusion.